Background: In this study, we will investigate the parasiticidal activity of selected indigenous plants extracts using established quantitative bioassays. These plants are well known in Ghana locally as folk medicines for helminthic, protozoal, and bacterial infections, but are uncharacterized in terms of their true potential as formal medical treatments. Once the relevant bioactivities of these plants are established using the bioassays, we will fractionate the extracts into their component fractions, and hone in on the individual chemicals responsible for the bioactivities measured for further investigation and chemical optimization at the Consortium for Neglected Tropical Diseases and One Health in Ghana