Background: This study aims to investigate the feasibility of integrating the Ov16 rapid test into onchocerciasis surveillance activities in Ghana based on the attributes of acceptability, usability and cost. Two approaches proven to be viable options to replace skin detection of microfilaria in the diagnosis of onchocerciasis are Polymerase Chain Reaction and Ov16 IgG4 based serology test. PCR is not practical for community surveillance in Sub-Saharan Africa because it is expensive to purchase and operate and requires highly skilled staff. ELISA based serological tests are also fraught with challenges including the need for analysis in the lab and lack of standardized commercially available Ov16 ELISA, resulting in variations in lab protocols. In 2014, a new, field-friendly, rapid diagnostic tool with potential for integration into current onchocerciases surveillance programmes in endemic countries was developed and made commercially available (SD BIOLINE Onchocerciasis IgG4 rapid test). The performance of the Ov16 rapid test has been evaluated in the field and current global research priorities focus on operational and implementation research to demonstrate utility and increase access of the Ov16 rapid test, particularly in low-prevalence communities which have had several rounds of ivermectin